VITADWASTE

Innovative and sustainable processes for the development of Vitamin D nutraceutical from fish waste: extraction, formulation and clinical study for the evaluation of its bioavailability and clinical equivalence

The pandemic crisis linked to Covid-19 highlights the importance of a healthy lifestyle and an adequate diet, including preventive substances against diseases, such as viral infections.

The bioeconomy represents a model of sustainable and resilient territorial growth that guarantees the recovery of high value-added products from renewable biological resources, such as by-products of the fishing industry.

Vitamin D is found in two forms, D2 (ergocalciferol) and D3 (cholecalciferol), with D3 being the primary storage form for all fish species, making them an excellent source of vitamin D3 for humans.

The project aims to use waste from fish production to extract, enrich, characterize and formulate nutraceuticals based on vitamin D3, studying their pharmacokinetics and bioequivalence in a clinical study.

Techniques such as microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) will be explored to extract vitamin D from fish waste, while biotechnological treatments will use proteolytic enzymes and lipases on the raw material to obtain better vitamin D yields .

Considering the growing awareness on the importance of vitamin D and the high prevalence of its deficiency (40% in Europe), fish waste could constitute ideal raw materials for the preparation of vitamin D nutraceuticals in a sustainable way.


Referent:

Emanuela Frapiccini

Researcher

Ancona

SCOPRI DI PIÙ


Programme: PRIN22


Duration: October 12, 2023 - October 11, 2025


Budget: 261.203,00 €


Budget IRBIM: 56.238,00 €


Contacts: emanuela.frapiccini@cnr.it


Areas of Research:

TEAM

Giuseppe Caccamo

Technical Collaborator

Ancona

Emanuela Frapiccini

Researcher

Ancona

Donato Giovannelli

Associate with Collaboration Assignment

Ancona

Monica Panfili

Technologist

Ancona

Research Projects



Referent:
Lucrezia Cilenti

To protect and maintain/restore the biodiversity and ecosystems of the Lesina Lagoon through management, maintenance/restoration and integrative monitoring of the NATURA 2000 site affected by fishing activities and through a participatory approach among stakeholders (policy makers, researchers, fishermen) who share responsibilities and interests on the lagoon ecosystem.

The research activities of the Institute are carried out in the context of research, development and innovation projects, both national and international, based on regional funding programs (POR FEAMPA - Regional Operational Program of the European Maritime Affairs Fisheries Fund and Aquaculture and POR FESR - Regional Operational Program of the European Regional Development Fund) or ministerial (PRIN - Projects of relevant national interest, PNRA - National Research Program in Antarctica, PO FEAMPA - National Operational Program European Maritime Affairs Fisheries and Aquaculture Fund) , programs for European Territorial Cooperation (Interreg), direct funding programs of the European Commission (Horizon2020 and Horizon Europe, Life, JPI - Joint Programming Initiatives, ERA-NET Cofund) and thematic collaboration initiatives managed by international organizations such as, for example , the FAO - GFCM (General Fisheries Commission for the Mediterranean). The Institute also develops funded projects in the context of collaborations with private companies in the sectors of the blue economy as well as technology transfer and research results. Research projects, mainly of a collaborative nature, are developed through a wide network of partners that include major Italian and foreign research institutions and universities.

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