Giuseppe Caccamo
Technical Collaborator
Ancona
The pandemic crisis linked to Covid-19 highlights the importance of a healthy lifestyle and an adequate diet, including preventive substances against diseases, such as viral infections.
The bioeconomy represents a model of sustainable and resilient territorial growth that guarantees the recovery of high value-added products from renewable biological resources, such as by-products of the fishing industry.
Vitamin D is found in two forms, D2 (ergocalciferol) and D3 (cholecalciferol), with D3 being the primary storage form for all fish species, making them an excellent source of vitamin D3 for humans.
The project aims to use waste from fish production to extract, enrich, characterize and formulate nutraceuticals based on vitamin D3, studying their pharmacokinetics and bioequivalence in a clinical study.
Techniques such as microwave-assisted extraction (MAE) and ultrasonic-assisted extraction (UAE) will be explored to extract vitamin D from fish waste, while biotechnological treatments will use proteolytic enzymes and lipases on the raw material to obtain better vitamin D yields .
Considering the growing awareness on the importance of vitamin D and the high prevalence of its deficiency (40% in Europe), fish waste could constitute ideal raw materials for the preparation of vitamin D nutraceuticals in a sustainable way.
Referent:
Programme: PRIN22
Duration: October 12, 2023 - October 11, 2025
Budget: 261.203,00 €
Budget IRBIM: 56.238,00 €
Contacts: emanuela.frapiccini@cnr.it
Areas of Research: